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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are typically focused on the practical aspects of the research design, like recruitment and consent as well as adherence to the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and included participants from different geographic areas. This type of heterogeneity that is crucial for a pragmatic trial to be valid and to reduce bias in the results is also essential. However, too much heterogeneity can result in problems with the design of the trial.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually requested by policy makers and practitioners to inform their decision making. They can also be used to determine the cause-effect relationship of an intervention and its effects. They should, however, not, be used to replace explanation studies.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial that include the recruitment process, 프라그마틱 무료체험 메타 the design and implementation of the intervention, and the follow-up.

There is a growing trend in the number of pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary-care settings.