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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of study design, including the recruitment and consent process, adherence, and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographic areas. This kind of heterogeneity is required for pragmatic trials to be able to prove their validity and also reduces the chance of bias in the results. A high degree of heterogeneity, 프라그마틱 추천 however could cause issues with the trial design.

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The aim of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policy makers and practitioners to inform their decision making. They can be used to determine the causality of an intervention with its outcomes. They should, however, not be used to replace the need for explanation studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study, including recruitment, design, 라이브 카지노 implementation of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.