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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described as focusing on practical aspects of design that include the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from different geographic areas. This type of heterogeneity, which is essential for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However excessive heterogeneity could result in problems with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are usually requested by practitioners and policymakers in order to inform their decisions. They also provide a useful method to determine the cause-effect relationship between an intervention and 프라그마틱 공식홈페이지 프라그마틱 무료체험 메타; Pragmatic-Korea43197.blogzag.com, its results. However, they shouldn't be used to substitute for the use of explanation studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study which includes the recruitment, design, and delivery of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatics. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.